摘要As countries continue to deal with the global COVID-19 pandemic and its consequences,policymakers recognize that science,technology,and innovation(STI)practices offer a means of addressing many of the health problems that arise from the ongoing pandemic.Such recognition has given rise to many STI policy initiatives across various areas of science and policy,leading to a better understanding of coronavirus and the development of COVID-19 vaccines,treatments,and diagnostics.However,the practical imple-mentation of vaccine and treatment strategies within local communities extends well beyond the laboratory.This study explored how misinformation and trust amplify or attenu-ate coronavirus and COVID-19 vaccine perceptions of those from ethnic minority groups deemed more susceptible to the impacts of the virus.Primary data in this study were col-lected in Scotland through semistructured interviews with 26 expert and nonexpert members from Scotland's minority ethnic communities.The study findings show that risk per-ception is fluid and dependent on the information and evi-dential environment in which people find themselves.Mis-information,fake news,conspiracies,and trust or distrust(from prior experiences and historic practices)influence the perception of coronavirus and how risk messages are received,including the acceptance of coronavirus vaccines.This article reflects on Scotland's approach to building trust and COVID-19 vaccine confidence and engagement based on the findings of this study,identifying areas of strength and areas for further improvement or research.The authors believe,as shown by our research,that vaccine engagement will be more impactful if developed by and with the public,and reflects public values,concerns,and priorities.