摘要Nasopharyngeal carcinoma (NPC) is the most common head and neck cancer in Southeast Asia and Southern China, for which simple radiotherapy or concurrent radiochemotherapy is a main treatment means, with good therapeutic effects. However, although local control rate and survival rate for NPC are improved, distant metastasis is still a main cause of treatment failure. In recent years, immunotherapy has become a focus in the field of cancer research and comprehensive treatment for cancer, and has obtained certain therapeutic effects in several tumors so far, such as melanin and lymphoma. Due to its advantages of high efficacy, good specificity and less side effects, immunotherapy has become a new promising alternative treatment for patients with NPC. This review was mainly focused on research progress of immunotherapy in NPC, specifically including adoptive immune cell therapy, tumor vaccine, checkpoint inhibitor, and immune gene therapy.