Research progress of HPV-associated oropharyngeal cancer

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摘要The incidence of oropharyngeal squamous cell carcinomas(OPSCC)is rising rapidly in recent years,while the pathologic mechanisms mediating tumorigenesis are heterogeneous and complex.Indeed,the proportion of OPSCCs mediated by human papillomavirus(HPV)is also increasing,which is named as HPV+OPSCC.In addition,HPV+OPSCCs have distinct biological characteristics,while their intratumoral cell heterogeneity and extratumoral immune microenvironment have guiding significance for clinical treatment decision making and prognosis prediction.In this review,we briefly summarize the overview of HPV and OPSCCs,and discuss the research progress of HPV+OPSCCs in detail.

作者 Yue Zhang ^[1] Yiqian Wang ^[1] Qing Li ^[2] Meihua Wang ^[3] 学术成果认领

作者单位 Department of Pathology,Changzhou Cancer Hospital Affiliated to Soochow University,Changzhou 213032,Jiangsu,China ^[1] Department of Pathology,Changzhou First People's Hospital Affiliated to Soochow University,Changzhou 213004,Jiangsu,China ^[2] Department of Pathology,Changzhou Cancer Hospital,Changzhou,China ^[3]

关键词 human papillomavirus oropharyngeal cancer squamous cell carcinomas

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Reviews

发布时间 2024-11-06

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