摘要Objective To explore the value of clinical application of a navigation system with three-dimensional(3D)imag-ing for thermal ablation of liver tumors.Methods The study cohort comprised 60 patients who underwent computer tomography-(CT)guided thermal ablation(radiofrequency or microwave ablation)of liver tumors in our department from August 2021 to October 2022.A random envelope method was used to allocate the study patients randomly to two groups of 30 patients each:a navigation and a control group.An intraoperative 3D imaging navigation system with CT guidance was used in the navigation group,whereas traditional CT guidance was used in the control group.During the thermal ablation process,the number of puncture needle adjustments,time to target puncture,and number of CT scans were recorded and compare between the two groups.Results The average number of punctures and needle adjustments was significantly lower in the navigation group(2.7±1.1 mins)than in the control group(4.9±3.7 mins).The average time taken to puncture the target was significantly shorter in the navigation group(11.3±4.2 mins)than in the control group(15.5±4.8 mins).There average number of CT scans was significantly smaller in the navigation group(4.5±1.6)than in the con-trol group(8.4±4.5)(all P<0.05).Conclusion Use of an intraoperative 3D imaging navigation system in thermal ablation of liver tumors can im-prove the accuracy of tumor thermal ablation puncture and reduce the number of punctures,number of CT scans,and average puncture time.Such systems can play an important role in the clinic.