摘要目的 了解柯萨奇病毒A组6型、肠道病毒71型手足口病临床特点,为指导临床诊断,调整手足口病防控策略提供科学依据.方法 采用前瞻性调查的方法,收集2013至2014年在北京市西城区手足口病临床确诊病例信息,将手足口病原核酸检测阳性的病例分为CA6、EV71组,分析比较2组的临床特点、流行特征、预后等.结果 CA6组130例,EV71组121例.2组的年龄、性别分布差异无统计学意义.CA6组发热比例高达82.3％,明显高于EV71组(34.7％,P＜0.05),其中大于等于38℃占85.0％.CA6组出现大疱疹(7.4％)、恢复期脱皮(16.9％)、脱甲(10.0％)的比例高于EV71组(P＜0.05).不同年份流行主要毒株不同.结论 与EV71感染相比,CA6感染引起的高热比例较高,部分病例可表现为大疱疹、脱皮、脱甲,整体预后较好.CA6和EV71感染所致的HFMD发病高峰季节不一致.

abstractsObjective To compare the clinical features of hand,foot and mouth disease (HFMD) caused by coxsackievirus A6 (CA6) and enterovirus 71 (EV71) infection,and to provide guidance for clinical diagnosis and prevention.Methods We collected the clinical diagnosed cases of HFMD a perspective study from 2013 to 2014 in Xicheng District.The cases were grouped into two,CA6 and EV71 infected,according to the result of nucleic acid detection.The clinical features,epidemiological characteristics and prognosis were compared between the groups.Results There were 130 cases infected with CA 6,and 121 cases with EV71.No statistical significances were found in age and sex.Among the CA6 infected HFMD cases,82.3％ had a fever,which was significantly more than the EV 71 infected (34.7％,P＜0.05％) and 85.0％ of the CA6 cases had a fever over 38℃.Large vesicles (7.4％),desquamation (16.9％)and onychomadesis (10.0％) were found in the CA6 infected cases,and was significantly than in the EV71 group (P＜0.05).The main epidemic strain shifted during 2013 and 2014.Conclusions Among CA6 infected cases high fever,large vesicles,desquamation and onychomadesis were more frequent than the EV71 infected ones.All the patients had a fine prognosis.