摘要脑源性神经营养因子是神经系统发育中的关键信号分子,与其特异性酪氨酸激酶受体B(TrkB)结合后可引发多种生理效应.目前作用机制尚不清楚,大量研究证明其可能与神经细胞生存、生长、分化、损伤后修复、凋亡等作用相关.该文分别对影响脑源性神经营养因子及其受体TrkB表达的因素,脑源性神经营养因子及其受体TrkB在儿童发育行为疾病中的作用及早期环境与二者表达的联系进行综述.

abstractsBrain-derived neurotrophic factor(BDNF) is a key signaling molecule during the development of nervous system.When BDNF is binded tyrosine kinase receptor B ( Trk B ),it can lead to a variety of physiological effects.Although the mechanisms of their action remain unclear,studies have proved that they may be related to effects of nerve cell survival,growth,differentiation,repair after injury and apoptosis,etc.This review describes the affecting factors in the expression of BDNF and TrkB,the effects of BDNF and TrkB in the development of behavioral disorders and the relationship with early environment.