摘要与接种三价灭活流感疫苗(trivalent inactivated influenza vaccine,TIV)相比较,接种减毒流感活疫苗(live attenuated influenza vaccine,LAIV)能明显提高2～17岁健康儿童及患呼吸道疾病、免疫缺陷病儿童的抗流感能力,能更有效预防儿童流感的发生,且不会提高儿童的急诊率和住院率,不会提高除鼻塞、流涕外,任何其他不良反应的发生率.LAIV能使儿童机体产生更强的抗流感免疫反应.接种LAIV1年后,其仍有较高的保护效力.经鼻腔接种LAIV方便且无痛苦,更容易被儿童和家长所接受.LAIV为预防儿童流感的发生提供了一条有效的途径.

abstractsLive attenuated influenza vaccine (LAIV) is a Live attenuated influenza vaccine.LAIV has demonstrated significantly greater protection against influenza in healthy children or children with a history of respiratory diseases or with immunodeficiency diseases 2 to17 years of age as compared with TIV.LAIV can prevent influenza more efficient without increasing hospitalization and emergency department visits as compared with TIV.Except for the runny nose and nasal congestion,no excess risk of adverse events have been found among children who were vaccinated with LAIV compared with those vaccinated with TIV.LAIV has the potential in children to stimulate greater local anti-influenza immune responses and its protective effect can extend beyond the year of administration.Vaccining LAIV is convenient and noninvasive for children,it is easily accepted by children and their parents.LAIV offers a effective approach to prevent influenza.