摘要肠道微生物对人类健康至关重要,早期肠道微生物的定植可影响婴幼儿的生长发育.微生物-肠-脑轴将肠道微生物与脑紧密相连,为肠道微生物和中枢神经系统提供了相互通信的桥梁,并与新生儿中枢神经系统并行发展.肠道微生物可通过代谢、免疫、迷走神经、神经内分泌等途径影响新生儿神经发育.肠道微生物还可通过参与调控紧密连接蛋白的表达,影响新生儿血脑屏障的通透性和完整性.目前,肠道微生物群调控新生儿神经发育的研究尚处于起步阶段,但逐渐成为研究热点,故该文对此进行综述.

abstractsGut microbiota may be important to human health.The early colonization of gut microbiota will affect the growth and development of infants.The microbiome-gut-brain axis connects the gut microbiota to the brain,providing a communication bridge for the gut microbiota and the central nervous system,and develops in parallel with the newborn central nervous system. Gut microbiota may affect neonate neural development through metabolism,immunity,vagus nerve and neuroendocrine.Gut microbiota may also affect the permeability and integrity of neonatal blood-brain barriers by regulating the expression of tightly linked protein. In recent years,the research of gut microbiota that may regulate neonate neural development is still in its early stage,but gradually becomes a hot research topic.