摘要氨基酸在蛋白质合成、免疫应答、神经内分泌调节以及器官功能成熟等生命活动的各个方面具有重要作用,与早产儿的生长发育和疾病发生密切相关.早产儿氨基酸的临床应用应在满足“追赶性生长”需要的同时,避免营养过量所致的不良预后.营养相关代谢组学研究为制定适宜的营养策略提供新的途径和方向:通过补充不同剂量氨基酸的对比进一步评估其有效性和安全性;通过给予不同种类氨基酸制剂的对比进一步讨论合理的氨基酸配比;通过早产儿与足月儿的对比进一步了解早产儿氨基酸代谢特点;通过不同营养状态的对比进一步探究氨基酸代谢与生长发育的联系等.

abstractsAmino acids play a significant role in various aspects of life activities such as protein synthesis,immune response,neuroendocrine regulation and organ development.They are also closely related to the growth of preterm infants and the risks of diseases.Clinical application of amino acids in preterm infants should meet the need for catch-up growth,while avoiding adverse prognosis caused by overnutrition.Nutrition-related metabolomics provides new approaches to appropriate nutrition strategies:assessing the effectiveness and safety of supplemental amino acids by comparing different doses of amino acids,discussing reasonable composition of amino acids by comparing different formulas,understanding the characteristics of amino acid metabolism in preterm infants by comparing newborns at different gestational ages,and exploring the relationship between metabolism and growth by comparing newborns at different nutritional status.