摘要过敏性紫癜肾炎(Henoch-Sch(o)nlein purpura nephritis,HSPN)是儿童最常见的继发性肾小球肾炎之一,重症HSPN患儿出现预后不良的风险明显升高.目前,国内外对重症HSPN的治疗方案缺乏统一性,影响患儿预后的因素也存在较多争议.该文就重症HSPN的治疗方案进行回顾分析,包括糖皮质激素、免疫抑制剂、利妥昔单抗和血浆置换,探讨影响HSPN长期预后的相关因素,为临床重症HSPN的治疗和管理提供参考.

abstractsHenoch-Sch(o)nlein purpura nephritis (HSPN) is one of the most common types of secondary glomerulonephritis in children.Patients with severe HSPN are at distinctively higher risk of poor prognosis.Currently,no unified therapeutic method is adopted to treat severe HSPN,and disagreements exist in prognostic factors.This paper reviews the treatment measures including steroid,multiple immunosuppressive agents,rituximab and plasmapheresis for severe HSPN.Relevant factors for long-term prognosis of HSPN are discussed,which provide reference for clinical treatment and management.