摘要哮喘是一种以可变的气道阻塞、气道高反应性和气道重塑为病理特征的慢性炎症性呼吸系统疾病.哮喘患者呼出气体中增多的一氧化氮(nitric oxide,NO)由诱导型一氧化氮合酶(inducible nitric oxide synthase,iNOS)催化氧化左旋精氨酸产生,iNOS在缺氧、缺血、炎症刺激等条件下被诱导大量表达,产生过量NO,并参与调节哮喘发病各个方面的调节,包括气道和血管平滑肌的紧张度和炎症反应.该文就NO与iNOS在哮喘中的研究进展作一综述.

abstractsAsthma is a chronic inflammatory respiratory disease characterized by variable airway ob-struction, airway hyperresponsiveness, and airway remodeling. In the respiratory tract, nitric oxide ( NO) is generated via oxidation of L-arginine that is catalyzed by inducible nitric oxide synthase ( iNOS) . In hypoxia-ischemia and inflammation processes, iNOS is induced to produce excessive NO, playing an important role in asthma, including the modulation of airway and vascular smooth muscle tone and the inflammation. This re-view focuses on recent research achievements regarding the relationship between NO and iNOS and asthma.