换一批
换一批摘要叶酸缺乏与胎儿脊柱裂、先天性心脏病等出生缺陷的发生有关,而母孕期通过增补叶酸可有效预防各类出生缺陷的发生,但叶酸补充过量又可能增加某些疾病的患病风险.该文将从叶酸缺乏的原因、叶酸代谢相关酶基因的单核苷酸多态性、叶酸缺乏引起出生缺陷的相关机制以及正确增补叶酸预防出生缺陷等方面进行综述.
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abstractsFolic acid deficiency is associated with birth defects such as fetal spina bifida and congenital heart disease. Folic acid supplementation during pregnancy can prevent various birth defects, but excessive fo-lic acid may increase the risk of certain diseases. This article reviews the causes of folate deficiency, single nu-cleotide polymorphisms of folate metabolism-related enzyme genes, the mechanism of birth defects caused by folic acid deficiency, and the correct supplementation of folic acid to prevent birth defects.
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关键词
叶酸缺乏出生缺陷单核苷酸多态性同型半胱氨酸Folic acid deficiencyBirth defectSingle nucleotide polymorphismHomocys-teine
主题词
先天畸形(Congenital Abnormalities)叶酸(Folic Acid)叶酸缺乏(Folic Acid Deficiency)多态性, 单核苷酸(Polymorphism, Single Nucleotide)半胱氨酸(Cysteine)
栏目名称
综述
DOI
10.3760/cma.j.issn.1673-4408.2019.09.006
发布时间
2019-10-16
基金项目
国家自然科学基金
辽宁省自然科学基金
National Natural Science Foundation of China
Liaoning Pro-vincial Natural Science Foundation
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