摘要肺动脉高压(pmlmonary arterial hypertension,PAH)是一种肺血管疾病,其发病机制十分复杂,可由各种因素引起,导致肺动脉压力异常增高,可以造成右心衰竭甚至死亡.为了进一步研究PAH的发病机制,有必要建立一种模型,使之能较好的模拟PAH的病理生理特征.PAH动物模型为研究PAH的发病机制、病理生理、发展、转归及治疗提供了有效的动物模型基础.经典的模型包括低氧法、药物注射法、手术分流法等.不同的动物模型各有优缺点,但仍没有一种PAH模型能够完全模拟PAH的发病机制.该文旨在对目前已知的动物模型进行归纳及整理,为PAH动物模型的选择及应用提供方向,使其能更好地模拟人类PAH.

abstractsPulmonary arterial hypertension (PAH) is a multifactorial pulmonary vascular disease accompanied by abnormal increase of pulmonary artery pressure with complicated pathogenesis,which leads to progressive right heart failure and death.It is necessary to establish an animal model that can simulate the pathophysiological characteristics of PAH in order to study the pathogenesis of PAH further.Animal models of PAH act as effective methods to study the pathogenesis,pathophysiology,development,prognosis and treatment of PAH.Classic PAH models include chronically hypoxia,drug injection,and so forth.Although animal models of PAH differ from each other,there is still no widely accepted animal model which can totally imitate human PAH.This review summarizes animal models of PAH in order to provide reference for choosing experimental animals of PAH and to establish a better animal model similar to human PAH.