摘要RGC-32 (response gene to complement 32)是一种重要的补体应答基因,广泛表达于组织和器官并参与了许多生物学过程,如细胞增殖与分化、细胞周期调控、炎症反应、免疫调节以及肿瘤形成等.作为重要的细胞周期调节因子,RGC-32蛋白通过调节细胞周期影响多种疾病发生发展的过程.近来研究表明RGC-32参与了肾小管损伤修复过程,其作用可能与其对细胞周期尤其G2/M期的调控有关.该文就RGC-32调控肾小管损伤修复的机制研究进展作一综述.

abstractsResponse gene to complement 32 (RGC-32) as an important response gene to complement was widely expressed in a lot of tissues and organs and participated in many biological processes such as cell proliferation and differentiation,cell cycle regulation,inflammation,immune regulation,and tumor,etc.As a cell cycle regulator,RGC-32 affected the development of numerous diseases by regulating the cell cycle.In recent years,many studies have shown that RGC-32 may be involved in the renal tubular injury and repair,and its role in the renal tubular injury and repair may be related to its regulation of cell cycle especially the G2/M.This article will make a brief review on the progress of the mechanism of RGC-32 regulating the renal injury and repair.