孕期双酚A及其类似物暴露对母婴健康影响的研究进展
Advances in the effects of exposure to bisphenol A and its analogues during pregnancy on maternal and infant health
摘要双酚A(bisphenol A,BPA)作为一种典型的环境内分泌干扰物,曾被广泛用于日常消费品中,因其存在生殖、发育、神经等多种生物毒性,逐渐被双酚F、双酚S、双酚AF等类似物替代。研究表明BPA及其类似物可经多种途径进入人体,已在人体血液、尿液、胎盘、母乳、羊水等组织样本中检出,并传递至胎儿体内,引起多种毒性效应,从而影响孕妇及胎儿的健康,并可能带来早产、流产、低出生体重等不良妊娠结局。该文就近年来孕期BPA及其类似物暴露的途径及现状,对孕妇及胎儿健康的影响进行综述,并从环境不良因素暴露的角度为母婴健康提出合理建议,有助于今后的研究。
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abstractsBisphenol A(BPA)as a typical environmental endocrine disruptor, has been widely used in daily consumer goods.It has reproductive, developmental, neurotoxicity and other biological toxicity, so it is gradually replaced by bisphenol F, bisphenol S, bisphenol AF and other analogues.Studies have shown that BPA and its analogues can enter the human body through many ways, have been detected in human blood, urine, placenta, breast milk, amniotic fluid and other tissue samples, and transmitted to the fetus, causing a variety of toxic effects, thus affecting the health of pregnant women and fetuses, and may lead to adverse pregnancy outcomes such as preterm delivery, abortion, low birth weight and so on.This article reviews the ways and current situation of exposure to BPA and its analogues during pregnancy in recent years, and its effects on maternal and fetal health, and puts forward reasonable suggestions for maternal and infant health from the point of view of exposure to adverse environmental factors, so as to provide inspiration for future research.
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