摘要变应原免疫治疗（allergen immunotherapy，AIT）可以通过免疫调节机制改变过敏性疾病的自然进程，并在治疗结束后仍能够维持疗效。AIT治疗有效的标志是诱导机体对特定过敏原产生免疫耐受，机制涉及多种免疫细胞的参与，包括效应T细胞、B细胞、树突状细胞、固有淋巴样细胞、肥大细胞和嗜碱性粒细胞等。研究发现，AIT治疗中外周血多种免疫细胞会发生变化，且一些免疫细胞的变化与AIT疗效相关，这或许可为实际诊疗活动提供一定的理论参考，可能成为预测和评估AIT疗效的潜在生物标志物。该文就外周血免疫细胞在AIT治疗中的变化作一综述。

abstractsAllergen immunotherapy（AIT）can alter the natural course of allergic diseases through immunomodulatory mechanisms and maintain the efficacy after completion. The induction of immune tolerance by AIT is considered to be effective treatment and the mechanism involves the participation of a variety of immune cells，including effector T cells，B cells，dendritic cells，innate lymphoid cells，mast cells and basophils. Studies have found that a variety of immune cells in peripheral blood changed during AIT treatment and the changes of some immune cells were related to the efficacy of AIT，which may provide some theoretical reference for practical clinical activities and may become potential biomarkers for predicting and evaluating the efficacy of AIT. This article reviews the changes of peripheral blood immune cells in the treatment of AIT.