摘要目的 评价单用99Tcm-硫胶体和99Tcm-硫胶体与亚甲蓝联合应用探测早期乳腺癌前哨淋巴结(SLN)的效能.方法 76例早期乳腺癌患者分为单用99Tcm-硫胶体组(25例)和99Tcm-硫胶体与亚甲蓝联合组(51例),分别在术前进行乳腺癌SLN探测,以腋窝淋巴结病理检查结果作为评价标准.结果 76例患者中成功探测到SLN 74例,SLN的检出率、准确率、灵敏度和假阴性率在99Tcm-硫胶体组分别为92.0％、95.7％、90.0％、10.0％；在联合组分别为100％、98.0％、95.2％、4.8％.结论 乳腺癌SLN探测可较准确预测腋窝淋巴结的转移状况,为外科医生确定手术方式提供重要信息,联合应用99Tcm-硫胶体和亚甲蓝可提高SLN的检出率和准确率,降低假阴性率.

abstractsObjective To compare the efficacy of 99Tcm-sulfur colloid and combined 99Tcm-sulfur colloid/methylene blue methods for detection of sentinel lymph node (SLN) in early breast cancer.Methods Seventy-six patients with early breast cancer were dived into two groups.In group 1 (n=25),99Tcm-sulfur colloid detection was used alone.In group 2 (n=51),both 99Tcm-sulfur colloid detection and methylene blue methods were used.The pathological findings of resected axillary lymph nodes were regarded as evaluation standard.Results In 76 patients SLN was successfully detected in 74 cases.The SLN detection rate,accuracy,sensitivity and the false negative rate for 99Tcm-sulfur colloid group and combined group were 92.0％ vs.100％,95.7％ vs.98.0％,90.0％ vs.95.2％,and 10.0％ vs.4.8％ respectively.Conclusions SLN detection in early breast cancer may accurately predict axillary lymph node metastasis,thus providing important information for surgery.Combined use of 99Tcm-sulfur colloid and methylene blue methods may improve the SLN detection accuracy and reduce false negative rate.