摘要目的:了解显微计算机体层摄影术（Micro-CT）应用于实验动物的研究现状并预测未来的研究热点和发展趋势。方法:检索Web of Science核心合集中的Science Citation Index Expanded数据库2014年1月1日至2024年7月31日发表的关于Micro-CT应用于实验动物研究的文献，运用CiteSpace 6.3.R1、VOSviewer 1.6.20、SCImago Graphica软件对纳入文献的文献类型、来源期刊、发文量、作者、国家、机构、关键词等内容进行可视化分析。结果:共纳入英文文献610篇，涉及来源期刊314种，其中，刊载量最高的期刊为 Bone（20篇），被引频次居首的期刊为 Journal of Bone and Mineral Research（409次）。Micro-CT应用于实验动物研究的相关文献的年发文量整体呈上升趋势，其中2021年发文量最高（67篇）。发文量最多的国家为美国（217篇），纳入文献作者共4 133名，来自1 130家机构，发文量超过10篇的机构共有7家，其中发文量最高的机构为巴西圣保罗大学（16篇），其次为比利时鲁汶大学（12篇）和瑞士伯尔尼大学（12篇）。涉及的机构多为高等院校、医学院校附属医院以及科研院所等。关键词共现分析、关键词聚类分析和关键词突现分析结果表明，骨相关的疾病模型研究（骨质疏松、骨关节炎）以及基础研究（表达、再生、细胞、组织、表面修饰），口腔种植术（牙龈卟啉单胞菌、口腔上颌窦提升术、牙科种植体），生物材料植入（植入物）是当前研究热点和发展动向。 结论:近10年来，Micro-CT在实验动物研究中的应用发展迅速，以美国为首的发达国家在该领域处于领先地位。骨相关的疾病模型研究以及骨相关的基础研究是该领域研究热点。但近年来的研究重点向Micro-CT在生物材料植入中的应用方向发展，可以作为未来研究方向的参考。

abstractsObjective:To understand the application of micro-computed tomography (Micro-CT) in laboratory animal research and predict research hotspots and development trends.Methods:Literature on the application of Micro-CT to laboratory animal research published from January 1, 2014 to July 31, 2024 was searched in the Web of Science Core Collection of Science Citation Index Expanded database. CiteSpace 6.3.R1, VOSviewer 1.6.20, and SCImago Graphica software were used to visually analyze the types, source journals, number of publications, authors, countries, institutions, and keywords of the included literature.Results:A total of 610 articles in English were included, involving 314 source journals; of which, the most published journal was Bone magazine (20 articles), and the most cited journal was Journal of Bone and Mineral Research(409 times). The number of articles related to Micro-CT application in laboratory animal research increased annually, and the highest number of articles was 67 in 2021. The United States was the country with the highest number of publications (217 articles). A total of 4 133 authors from 1 130 institutions were included in the literature, and 7 institutions had more than 10 publications. The highest number of publication was from the University of S?o Paulo, Brazil (16 articles), followed by the University of Leuven, Belgium (12 articles) and the University of Bern, Switzerland (12 articles). Most of the organizations involved were institutions of higher learning, hospitals affiliated with medical schools and research institutes, etc. The results of keyword co-occurrence, keyword clustering, and keyword burst analyses indicated that the hotspots of current research and the development trend included bone-related disease modeling research (osteoporosis, osteoarthritis) as well as basic research (expression, regeneration, cells, tissue, and surface modification), oral implantation ( Porphyromonas gingivalis, oral maxillary sinus lift, and dental implant), and biomaterials implantation (implant). Conclusions:In the past decade, the application of Micro-CT in laboratory animal research has developed rapidly. Hotspots included bone-related disease models and bone-related basic research. The application of Micro-CT in biological implants is a current research hotspot and a future development trend.