摘要目的:探讨积极情绪、投入、人际关系、意义以及成就(PERMA)理念下多维度支持对晚期恶性肿瘤化疗患者希望水平和不良反应的影响。方法:选取2021年1月至2021年12月就诊于靖江市人民医院肿瘤科的80例晚期消化道肿瘤患者，采用简单随机分组将患者分为观察组和对照组，各40例。对照组接受常规护理，观察组在对照组基础上接受PERMA理念下的多维度支持。于干预前和干预2个月后，比较两组体质指数(BMI)、白蛋白(ALB)、血红蛋白(Hb)等营养指标，比较Herth希望量表(HHI)评分、Piper疲乏量表(PFS)评分以及生活质量评定问卷(QOL)得分。记录两组在护理期间的不良反应发生情况。结果:干预后，观察组BMI、ALB和Hb水平均明显高于对照组( P<0.05)，HHI评分明显高于对照组( P<0.05)，PFS评分明显低于对照组( P<0.05)，躯体功能、心理功能、社会功能和物质功能等维度QOL评分均明显高于对照组( P<0.05)。观察组患者中胃肠道反应、骨髓抑制、口腔炎的发生率均明显低于对照组( P<0.05)。 结论:PERMA理念下多维度支持可以明显改善晚期消化道肿瘤患者的营养状况，提高希望水平，减轻疲乏症状，降低不良反应的发生率。

abstractsObjective:To investigate the effects of multidimensional support under the concept of Positive Emotions, Engagement, Relationships, Meaning and Achievement (PERMA) on the level of hope and adverse effects in patients undergoing chemotherapy for advanced malignancies.Methods:Eighty patients with advanced gastrointestinal tumors who attended this Hospital from January to December 2021 were selected, and the patients were divided into the observation group and the control group using simple randomization grouping, with 40 cases each. The control group received conventional care, and the observation group received multidimensional support under the PERMA concept on the basis of the control group. Nutritional indicators such as body mass index (BMI), albumin (ALB), hemoglobin (Hb), Herth Hope Inventory (HHI) scores, Piper Fatigue Scale (PFS) scores and Quality of Life Questionnaire (QOL) scores were compared between the two groups before and after 2 months of intervention. The occurrence of adverse reactions during the nursing period was recorded in both groups.Results:After the intervention, BMI, ALB and Hb levels were significantly higher in the observation group than in the control group ( P<0.05), HHI scores were significantly higher than in the control group ( P<0.05), PFS scores were significantly lower than those of the control group ( P<0.05), and QOL scores for the dimensions of somatic functioning, psychological functioning, social functioning, and material functioning were significantly higher than those of the control group ( P<0.05). The incidence of gastrointestinal reactions, myelosuppression and stomatitis were significantly lower in the observation group than in the control group ( P<0.05). Conclusions:Multidimensional support under the PERMA concept can significantly improve the nutritional status of patients with advanced gastrointestinal tumors, increase the level of hope, reduce the symptoms of fatigue, and decrease the incidence of adverse effects.