摘要信号转导及转录激活因子6(signal transducer and activator of transcription 6,STAT6)在支气管哮喘(简称哮喘)的发病机制中起重要作用,可促进Th2细胞优势分化和调节嗜酸粒细胞参与气道炎症等.过氧化物酶体增殖活化体受体γ(peroxisome proliferator-activated recepto-γ,PPAR-γ)可抑制多种细胞因子、炎症介质的释放及炎症细胞的功能,从而减轻气道炎症并抑制气道重塑等.糖皮质激素是当前控制哮喘发作最有效的药物,它可降低哮喘气道炎症和高反应性.近年研究表明糖皮质激素与PPAR-γ之间有协同抗炎作用,增强抗炎效应,且两者均可对STAT6产生影响.本文综述了STAT6在哮喘炎症中的作用及PPAR-γ和糖皮质激素对哮喘的影响,为哮喘的临床治疗探讨新的思路.

abstractsSignal transducer and activator of transcription 6 (STAT6) are important in the pathogenesis of bronchial asthma(asthma), which regulate the activity of Th2 cell and the development of airway inflammation by eosinophilia. Peroxisome proliferator-activated receptor-γ(PPAR-γ) proves to inhibite the airway inflammation and remodeling by reducing the release of cytokine and inflammatory mediators,and by down-regulating the function of inflammatory cells. Recent studies suggested that PPAR-γ and glucocorticoid has a coordinated antiinflammatory effects, and moreover, both PPAR-γ and glucocorticoid could obviously inhibit STAT 6. In order to provide another way for asthma clinical therapy, the article reviews the functions of STAT 6 in the inflammation of asthma,and the effects of PPAR-γ and glucocorticoid on the treatment of asthma.