摘要表观遗传学是指无DNA序列变化、可遗传的基因表达的改变.表观遗传学的分子机制主要包括DNA甲基化及组蛋白修饰,这些生物大分子的修饰在细胞周期,基因组印记、X染色体的失活中起重要作用.表观遗传学的改变与肿瘤及肺癌的发生、发展密切相关,它在疾病中的重要性越来越受到关注,表观遗传学的改变有可能成为新的诊断、监测及治疗的工具.

abstractsEpigenetics is the study of heritable changes in gene expression that occurs without changes in DNA sequence. Epigenetics mechanism mainly includes DNA methylation and histone modification,which play an important role in the cell cycling, physiological processes of genomic imprinting and X chromosome inactivation. Epigenetic aberrations are critical for carcinogenesis in lung cancer and other tumors, its importance is more and more recognized. Many researches have focused on the potential biological role of epigenetic changes with promise of novel diagostic,monitoring and therapeutic tools.