摘要目的 分析姊妹同患结节病的临床特点.方法 对姊妹同患结节病的临床资料进行分析并结合文献复习.结果 姐妹均表现为咳嗽,血清血管紧张素转换酶升高及肺门、纵隔淋巴结肿大,而妹妹表现为全身结节病,姊妹俩对糖皮质激素均有较好的效果.结论 结节病是一种多系统受累而原因未明的肉芽肿性疾病,该病有家族聚集倾向,遗传和环境因素共同参与了该病的发生,糖皮质激素是治疗的主要手段.

abstractsObjective To analyze the clinical feature of sarcoidosis with two sisiters. Methods The clinical data of sarcoidosis with two sisiters were retrospectively analyzed and relevant literatures were reviewed. Results Two sisters had a cough, serum angiotensin converting enzyme increased, and their hilar or mediastinal lymph nodes tumefied. The younger sister had sarcoidosis all over the body. Two patients showed good clinical response to glucocortieosteroid. Conclusions Sarcoidosis is a muhisystemic granulomatous disease of unknown etiology and has the feature of familial clustering. Both hereditary and environmental factors are involved in the pathogenesis of the disease in commom. Glucocorticosteroid is the main therapy.