换一批
换一批摘要缺氧诱导因子是细胞在低氧条件下产生的具有转录活性的核蛋白,调节着低氧应激下上百种基因的表达.近年来,对于缺氧诱导因子在肺内作用的研究日趋完整.该文就缺氧诱导因子的生物学特点及其在肺发育和肺疾病,包括肺动脉高压、肺癌和肺损伤中作用的研究进展作一综述.
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abstractsHypoxia inducible factors (HIF) are nucleoprotein with transcriptional activity produced by cells under hypoxic condition,which can modulate the expression of about 100 genes under hypoxic stress.In recent years,the studies about the role of HIF in lung development and lung disease are maturing.This article makes a summary on the biological characteristics of HIF and their effect on pulmonary hypertension,lung cancer and lung injury.
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