换一批microRNA介导的基因工程病毒减毒株研究进展
Advances in research of microRNA-mediated gene engineering attenuated strain of virus
摘要为了安全有效地进行基因治疗,需要把转染的基因限制在特定组织中表达.应用miRNA调节病毒基因表达是一个新方法.在miRNA介导的转基因表达系统中,可以将与miRNA互补的靶序列串联插入病毒基因3'非编码区域,导致在miRNA高表达细胞中抑制病毒的表达.我们总结了miRNA介导的病毒减毒株的应用.
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abstractsFor safe and effective gene therapy,targeted tissue-restricted transgene expression is desirable.A new system which can regulate viral gene expression by exploiting microRNA (miRNA) has recently been developed.In miRNA-mediated transgene expression systems,tandem copies of sequences perfectly complementary to the miRNA are usually incorporated into the 3'-UTR of the viral gene,leading to the suppression of viral expression in cells expressing the corresponding miRNA.The aim of this review is to highlight the use of miRNA-mediated attenuated strain of virus.
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DOI
10.3760/cma.j.issn.1673-436X.2014.22.012
发布时间
2015-04-15（万方平台首次上网日期，不代表论文的发表时间）
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