摘要目的 通过分析大气中各污染物浓度与慢性阻塞性肺疾病急性加重(AECOPD)每月入院人数的相关性.探讨大气污染物对AECOPD病情的影响,为大气污染防控及预防AECOPD提供意见.方法 选择太原市某三甲医院,收集其2014至2016年3年呼吸内科每月以确诊的AECOPD住院人数.同时收集2014至2016年太原市每天大气污染数据,对每月的大气污染物平均浓度与AECOPD入院人数进行Spearman秩相关分析.结果 AECOPD月住院人数与二氧化硫(SO2)、一氧化碳(CO)、臭氧8小时(O3～8 h)、细颗粒物(PM2.5)浓度及雾霾天数的秩相关系数分别为0.434、0.508、-0.465、0.362、0.444(P值均＜0.05).老年男性AECOPD患者的月住院人数与CO浓度及雾霾天数呈正相关,与O3～8 h浓度呈负相关;除此,老年女性AECOPD患者的月住院人数与SO2、PM2.5呈正相关;二氧化氮(NO2)浓度与AECOPD患者住院的性别差异无统计学意义.结论 大气污染物浓度对老年AECOPD的发病有着一定影响.老年AECOPD住院人数与NO2无明显相关性,与O3～8 h呈负相关.老年女性AECOPD患者对SO2、PM2.5较敏感.

abstractsObjective To evaluate the correlation between the atmospheric pollutant concentrations and the hospital admissions for acute exacerbation of chronic obstructive pulmonary disease (AECOPD).Methods Daily data on inpatient visits to a Grade Ⅲ Class A Hospital in Taiyuan city for AECOPD and daily air pollution data in Taiyuan City from 2014 to 2016 were collected.Spearman correlation analysis was applied to examine the association between the atmospheric pollutant concentrations and the hospital admissions for AECOPD.Results The coefficient of rank correlation between monthly average hospital admissions for AECOPD and monthly average concentrations of SO2,CO,O3～8 h,PM2.5 was correspongingly 0.434,0.508,-0.465,0.362 and 0.444 (all P ＜0.05).In the meanwhile,monthly average hospital admissions of elderly man for AECOPD was positively related to monthly average concentrations of CO and fog and haze days,however,negatively to monthly average concentrations of O3 ～8 h in this study.Whereas a positive correlation between that of elderly woman and monthly average concentrations of SO2 and PM2.5 was found.NO2 concentration showed no statistical significance concerning the gender of the AECOPD inpatient.Conclusions The ambient air pollutant concentrations are associated with the hospital admissions for AECOPD to some degree.However,there is no evident association between NO2 concentration and the elderly AECOPD inpatients,but,a negative association between O3 ～ 8 h concentration and the elderly AECOPD inpatient.Elderly woman for AECOPD was more susceptible to concentrations of SO2 and PM2.5.