摘要慢性阻塞性肺疾病(COPD)是一种呼吸系统常见的慢性疾病,在其发生发展过程中,炎症反应是导致一系列病理生理改变的重要机制.临床上评估慢性阻塞性肺疾病急性加重期(AECOPD)主要以临床症状改变为主,尚缺乏敏感的客观指标.研究发现多个炎症介质与AECOPD、病情严重程度和病情进展相关.现针对AECOPD潜在生物标记物作一综述,探讨这些炎症介质作为AECOPD生物标记物的价值和缺陷,旨在为临床提供AECOPD早期识别生物标记物和监测手段.

abstractsChronic obstructive pulmonary disease (COPD) is a common chronic disease in respiratory system.In the course of development,inflammatory response is an important mechanism leading to a series of pathophysiological changes.Clinical evaluation of acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is mainly based on clinical symptoms and lack of sensitive objective indicators.Many studies found that multiple inflammatory mediators were associated with AECOPD,severity and progression of the disease.This paper summarizes the potential biomarkers of AECOPD,to investigate the value and defects of these inflammatory mediators as AECOPD biomarkers,aiming to provide early identification of biomarkers and monitoring methods for AECOPD.