摘要慢性阻塞性肺疾病(COPD)是以持续气流受限为特征的可以预防和治疗的呼吸道疾病.其发生机制尚未完全明确,近年来许多研究表明氧化应激、基因多态性在其发生、发展过程中起到非常重要的作用.血红素加氧酶1 (HO-1)作为体内重要的氧化还原酶,与COPD关系密切.本文将从HO-1与COPD的发生、发展、治疗及预后等方面的关系进行综述,以期为COPD的诊断、治疗及管理提供新思路.

abstractsChronic obstructive pulmonary disease (COPD) is a preventable and treatable respiratory disease characterized by persistent airflow limitation.Its mechanism has not yet been fully clarified.In recent years,many studies have shown that oxidative stress and gene polymorphism play a very important role in its development.Heme oxygenase-1 (HO-1) is an important oxygen reductase in the body and is closely related to COPD.This article reviews the relationship between the occurrence,development,treatment and prognosis of HO-1 and COPD,in order to provide new ideas for the diagnosis,treatment and management of COPD.