摘要目的:探讨慢性阻塞性肺疾病(COPD)、哮喘及哮喘-慢阻肺重叠综合征(ACO)患者深吸气量(IC)与健康相关生存质量(HRQoL)的相关性，评估IC在HRQoL预测中的应用价值。方法:采用多级分层整群抽样方法。将来自2012-2013年间中国肺部健康横断面随机分层抽样研究纳入的5 271名上海市成人居民，根据肺功能结果分为COPD组、哮喘组、ACO组、其他慢性呼吸系统疾病组和健康组。收集的数据包括肺功能检查结果、健康调查12项简表(SF-12)和COPD CAT量表数据。采用Spearman相关系数评价肺功能指标与上述HRQoL量表结果的相关性。结果:与COPD组比较，通气功能障碍在ACO组更重，哮喘组较轻( P值均<0.05)。在COPD组、ACO组、其他慢性呼吸系统疾病组和健康组中，IC均与年龄呈负相关( P值均<0.05)。在各组患者中IC与其他肺功能指标均呈正相关( P值均<0.05)，且相关性在ACO组中最显著。ACO组中IC与SF-12躯体健康评分、CAT评分的相关性均较其他组更显著。ACO组中IC与CAT评分的负相关性较其他肺功能指标更显著(ρ＝-0.45， P<0.001)。 结论:IC是影响ACO患者生存质量的重要肺功能指标，在评估ACO患者疾病严重程度中有应用价值。

abstractsObjective:To evaluate the correlation between inspiratory capacity (IC) and health-related quality of life (HRQoL) and assess the role of IC in predicting HRQoL in patients with chronic obstructive pulmonary disease (COPD), asthma, or asthma-COPD overlap syndrome (ACO).Methods:Multilevel stratified cluster sampling method was used.We used a dataset of 5 271 adult residents in Shanghai who participated in cross-sectional stratified random sampling China Pulmonary Health study between 2021 and 2013.Participants were classified into five groups including COPD, asthma, ACO, other pulmonary disease, and healthy group.Results of spirometry tests were used, and HRQoL were evaluated by 12-Item Short Form Survey (SF-12) and COPD assessment test (CAT). We evaluated the associations between parameters of spirometry test and HRQoL scores using Spearman correlation coefficient.Results:Ventilatory dysfunction was more severe in ACO group, and relatively milder in asthma group when compared with COPD group.IC was negatively correlated with age in COPD, ACO, other pulmonary disease, and healthy group (all P<0.05). IC was positively correlated with other spirometry parameters in all groups (all P<0.05), with the correlation stronger in ACO group.IC was correlated with SF-12 score and CAT score in ACO group.For participants in ACO group, the correlation of IC with CAT score was stronger than with other spirometry parameters (ρ=-0.45, P<0.001). Conclusions:Our study suggested that IC is an important spirometry parameter that is related to quality of life in ACO patients, thus IC should be underlined in assessing disease severity of ACO.