摘要阻塞性睡眠呼吸暂停(OSA)是一种以睡眠期间反复发现上呼吸道阻塞为特征的疾病，发病率高，病理生理学机制复杂，涉及上呼吸道解剖结构异常以及非解剖学因素两个方面，后者包括上呼吸道神经肌肉反应性损害、呼吸控制不稳定(高环路增益)以及低觉醒阈值。动物模型是研究OSA病理生理特征的重要手段，对于探讨OSA潜在药理学靶点也具有重要意义。本文介绍了基于OSA不同病理生理特征动物模型的评价方法。

abstractsObstructive sleep apnea (OSA) is a highly prevalent disease characterized by repeated obstruction of the upper airway during sleep.It has a complex pathophysiology involving abnormal upper airway anatomy and non-anatomical factors.Non-anatomical traits include a compromised neuromuscular response of the upper airway to obstruction, an unstable respiratory control (high loop gain), and a low arousal threshold.Animal models play important roles in studying pathophysiological traits of OSA and in identification of potential pharmacological targets on OSA.This article describes evaluation methods of animal model based on different pathophysiological features of OSA.