摘要目的:分析鹦鹉热衣原体肺炎的临床表现及辅助检查特征，旨在提高对该病的认识及诊疗水平。方法:收集首都医科大学大兴教学医院2021年5月至2022年3月基于宏基因组二代测序(mNGS)诊断的鹦鹉热衣原体肺炎病例8例，分析其临床表现、实验室检查、影像学表现及治疗经过。结果:8例患者中，男3例，女5例，中位年龄55岁，年龄范围为42~76岁。7例有禽类接触史，主要表现为高热(8/8)、咳嗽(7/8)、头痛(5/8)、呼吸困难(4/8)。白细胞计数大多正常(6/8)，C反应蛋白升高(8/8)，肝酶、心肌酶升高(5/8)，血钠降低(4/8)，凝血功能异常(8/8)。8例患者胸部CT均表现为大片斑片实变影，单肺病变(7/8)，右侧为主，2例伴胸腔积液。诊断后给予四环素类、大环内酯类或喹诺酮类药物治疗，7例好转出院，1例死亡。结论:鹦鹉热衣原体肺炎通常表现为高热、咳嗽伴肺部斑片实变影，对临床可疑病例应加强询问流行病学史，尽早行mNGS检测明确病原体，及时针对性抗感染治疗。

abstractsObjective:To analyze the clinical manifestations, laboratory test results, and imaging features of 8 patients, so as to improve the understanding and clinical treatment of Chlamydia psittaci pneumonia.Methods:Eight cases of Chlamydia psittaci pneumonia diagnosed based on metagenomic next-generation sequencing (mNGS) in Daxing Teaching Hospital of Capital Medical University from May 2021 to March 2022 were collected.The clinical manifestations, laboratory tests, imaging findings and treatment course were enrolled.Results:A total of 3 males and 5 females, aged from 42 to 76 years (median 55 years), were included in this study.Seven cases had a clear history of exposure to poultry.All patients presented with high fever (8/8), followed by cough (7/8), headache (5/8), and dyspnea (4/8). The leukocyte count was normal in most patients (6/8). However, we observed increased liver and cardiac enzymes (5/8), decreased blood sodium (4/8), and abnormal coagulation function (8/8). The chest CT of all patients showed patchy consolidation, most of which were single lung lesions (7/8), mainly on the right side, with 2 cases having pleural effusion.All patients were treated with tetracyclines, fluoroquinolones, and macrolides after being diagnosed with mNGS.Seven patients recovered and were discharged, and 1 patient died.Conclusions:Chlamydia psittaci pneumonia showed certain characteristics, including high fever and cough with large pulmonary patchy consolidation.To the suspected clinical cases, epidemiological history should be investigated, and they should be diagnosed by mNGS as soon as possible so as to initiate targeted anti-infective therapy.