摘要个体肺功能在生命历程中呈现出动态变化的特征，其发展轨迹可分生长期、平稳期和衰退期三个阶段。流行病学研究显示，人群中存在显著的肺功能轨迹异质性，低于平均水平的轨迹与较差的健康结局相关，而高水平的轨迹则与健康老龄化相关。本文重点回顾了与慢性阻塞性肺疾病（慢阻肺病）相关的肺功能轨迹纵向队列研究，这些研究探索了慢阻肺病患者肺功能轨迹的特点及其影响因素，揭示了慢阻肺病的早期起源，让人们认识到肺功能异常可能在生命早期就有致病根源，并且可以在年轻人身上发现，强烈提示了尽早开始肺功能评估有助于前移慢阻肺病防控的窗口。展望未来，如何将肺功能轨迹分析转化为可操作的临床决策工具是需要关注的问题。

abstractsIndividual lung function exhibits dynamic changes throughout the lifespan,characterized by three developmental stages of growth,plateau,and decline.Epidemiological studies reveal a significant heterogeneity in lung function trajectories across populations.Trajectories below average are correlated with adverse health outcomes,while high-level trajectories are associated with healthy aging.This article reviewed longitudinal cohort studies on chronic obstructive pulmonary disease (COPD)-related lung function trajectories,in which the characteristics and influencing factors were explored.These studies highlighted the early origins of COPD,demonstrating that lung function abnormalities may originate in early life and manifest in young adults.This strongly suggested that initiating lung function assessments earlier could shift the COPD prevention window forward.Moving forward,transforming trajectory analysis into actionable clinical decision-making tools remains a critical challenge to address.