摘要目的 了解河南商城地区可能存在的蜱媒传染病的感染情况.方法 通过现场调查和实验室检测相结合的方法,对该地区病例、媒介蜱和宿主动物进行了调查.对43例病例的临床表现和实验室检测进行回顾性分析.用PCR和序列测定方法对媒介蜱和啮齿类宿主动物样本中查菲埃立克体、无形体、Q热立克次体的感染进行检测.结果 病例临床表现以发热伴白细胞、血小板减少和多脏器功能损害为主.3只全沟硬蜱PCR扩增阳性,其中1只同时感染嗜吞噬细胞无形体和Q热立克次体,2只单独感染嗜吞噬细胞无形体.宿主动物样本中有2只为无形体感染.结论 河南商城地区存在无形体、Q热立克次体的感染,应引起公共卫生部门的高度重视.

abstractsObjective To study the existence of tick-borne disease in Shangchen, Henan. Methods Epidemiologic, clinical data were collected by interviewing patients and retrieving medical records. Using polymerase chain reaction assays (PCR) and sequence analysis, Ehrlichia chaffeensis, Anaplasma, Coxiella burnetii were detected in ticks and rodents samples. Results Most patients had a moderately severe febrile illness with thrombocytopenia, leukopnia and organ failure. One Ixodes persulcatus was coinfection with Anaplasma phagocytophilum and Coxiella burnetii, while two Ixodes persulcatus were infection with Anaplasma phagocytophilum. Two rodents samples were positive with Anaplasma . Conclusions Anaplasma phagocytophilum and Coxiella bumetii exist in Shangcheng. Local public health authorities should pay much attention to these pathogens.