换一批
换一批摘要HIV感染者在没有抗病毒治疗的情况下其病毒复制控制在＜50拷贝/mL水平的,被称为杰出控制者(EC),这些患者也被称为杰出抑制者,或是HIV控制者,同时他们又区别于传统的长期不进展者,在没有抗病毒治疗的情况下能维持稳定的CD4细胞数以及无症状状态.此文对这类患者中被认为在控制病毒复制中发挥作用的效应机制进行了综述.
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abstractsHIV-1 infected patients whose viral replication can control to a level of ＜ 50 copies/mL without antiretroviral therapy are called elite controllers (EC). These patients are also known as elite suppressors, or HIV controllers, and they differ from traditional long-term non-progressors who maintain stable CD4 counts and are asymptomatic without antiretroviral therapy. In this article, the effective mechanisms that are thought to play a role in the remarkable control of viral replication in these patients are reviewed.
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主题词
免疫(Immunity)感染(Infection)获得性免疫缺陷综合征(Acquired Immunodeficiency Syndrome)病毒(Viruses)病毒复制(Virus Replication)
分类号
R512.91
栏目名称
综述
DOI
10.3760/cma.j.issn.1673-4149.2011.03.014
发布时间
2011-09-08
基金项目
北京市科学技术委员会资助项目
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