摘要当前，SARS-CoV-2各变异株之间交叉中和活性的下降提示出现不同的血清型。对病毒进行血清分型是多价/广谱疫苗研究的重要参考依据，也是疫情防控的重要指导。近日已有文献基于血清中和数据对SARS-CoV-2的抗原性分化和血清分型进行了研究和讨论。因此，本文对SARS-CoV-2血清分型的必要性、最新进展和重要价值进行综述。

abstractsThe diminishing cross-neutralization activity among SARS-CoV-2 variants indicates that distinct serotypes of SARS-CoV-2 have emerged. Understanding the viral serotypes is crucial for the development of multivalent/broad-spectrum vaccines and serves as a pivotal guide for epidemic prevention and control. Recent literatures have discussed the antigenic differentiation and serotyping of SARS-CoV-2 based on serum neutralization data. Therefore, this review aims to provide an overview of the necessity, recent advances and the significance of SARS-CoV-2 serotype classification.