摘要目的 探讨膀胱癌组织中P-糖蛋白(P-gp)和谷胱甘肽S转移酶(GST-π)与CerbB-2、层黏连蛋白受体(LN-R)的表达及其临床意义.方法 回顾性分析膀胱癌的临床与病历资料,应用免疫组织化学方法检测45例膀胱异性细胞癌中P-gp、GST-π和CerbB-2、LN-R基因的表达情况.结果 P-gp、GST-π、CerbB-2和LN-R在膀胱癌中的阳性率分别为42.22%、48.88%、46.66%和37.78%.P-gp、GST-π与CerbB-2在膀胱癌中的表达分级、分期比较差异有统计学意义(p＜0.05);LN-R在转移/未转移病例的表达中比较差异有统计学意义(p＜0.05);P-gp、GST-π与LN-R在2年内复发肿瘤的阳性率高于2年后复发肿瘤,相互间差异具有统计学意义(p＜0.05).结论 P-gp、GST-π、CerbB-2表达与膀胱癌的分期、分级、复发等呈正相关(p＜0.05),随肿瘤分级、分期、浸润性增高,其阳性表达率亦增高,同时P-gp、GST-π可指导膀胱癌化疗药物的选择;LN-R的表达与膀胱癌的转移呈正相关(p＜0.05),可作为判断膀胱癌预后的因素.

abstractsObjectives To investigate bladder cancer P - glycoprotein ( P - gp) and g, lutathione S transferass (GST-π) and CerbB-2, laminin receptor (LN -R) expression and clinical significance. Methods Retrospective analysis of bladder cancer and medical records, were detected by immunohistochemistry in 45 cases of bladder cell carcinoma of the opposite sex in the P - gp, GST - π and CerbB -2, LN - R gene expression. Results P - gp, GST - r, CerbB -2 and LN - R in bladder cancer, the positive rate was 42.22%, 48.88%, 46.66%and 37.78%. P -gp, GST- r and CerbB -2 expression in bladder cancer grade, stage the difference was statistically significant( p<0.05);LN-Rin the transfer / no transfer of cases to compare differences in the expression of statistically significant (p<0.05);P-gp,GST-π and LN - R tumor recurrence within 2 years, the positive rate of tumor recurrence after 2 years, statistically significant differences between each other ( p<0.05). Conclusions P-gp, GST-π, CerbB - 2 expression and bladder cancer stage, grade, recurrence was a positive corelation( p<0.05), with the tumor grade, stage, invasive increased, the positive expression rate also increased,while P - gp, GST - π can guide the choice of chemotherapy of bladder cancer; LN - R expression and metastasis of bladder cancer was positively correlated( p<0.05), could be used as prognostic factors in bladder cancer.