摘要目的 探讨灯盏花素辅助治疗对体外冲击波治疗肾结石所致肾损伤的保护作用.方法 收集2015年1月至2017年1月本院收治的120例肾结石患者为研究对象,采用随机数字表法将其均分为对照组和研究组各60例,对照组实施体外冲击波治疗,研究组另实施灯盏花素辅助体外冲击波治疗,观察治疗前后两组血清相关因子[血清内皮素1(ET-1)、丙二醛(MDA)、肾损伤分子-1(Kim-1)]、肾损伤生化指标[尿素氮(BUN)、β2微球蛋白(β2-MG)、尿N-乙酰-β-D氨基葡萄糖苷酶(NAG)]、临床疗效及预后效果[世界卫生组织生存质量测定量表(WHOQOL-BRFE)评分].结果 治疗前两组ET-1、MDA、Kim-1、BUN、β2-MG、NAG、WHO-QOL-BRFE评分相较无明显差异(P＞0.05);治疗后两组ET-1、MDA、BUN、WHOQOL-BRFE各项评分较治疗前明显升高,Kim-1、β2-MG、NAG明显降低,且治疗后研究组的各项指标变化较对照组明显,差异有统计学意义(P＜0.05);治疗后研究组总有效率90.00％(54/60)较对照组75.00％(45/60)明显高,差异具有统计学意义(P＜0.05).结论 灯盏花素辅助治疗体外冲击波治疗肾结石所致肾损伤患者的临床疗效显著,其通过有效调节血清相关因子和肾损伤生化指标,最终达到提高临床疗效和预后生活质量的目的.

abstractsObjective To investigate the protective effects of breviscapine in renal injury caused by extracorporeal shock wave therapy for renal calculi.Methods Totally 120 patients with renal calculi treated in our hospital from January 2015 to January 2017 were selected and randomly divided into the control group and the study group with 60 cases in each group.The patients in the control group were treated with extracorporeal shock wave,and patients in the study group were treated with breviscapine assisted extracorporeal shock wave.Serum related factors [serum endothelin 1 (ET-1),malondialdehyde (MDA),kidney injury molecule-1 (Kim-1)],biochemical parameters of renal injury [blood urea nitrogen (BUN),β2 microglobulin (β2-MG),urinary N-acetyl β-D glucosaminidase (NAG)],clinical curative effect and prognosis [the World Health Organization Quality of Life Scale (WHOQOL-BRFE) score] were observed before and after treatment.Results There were no significant differences in ET-1,MDA,Kim-1,BUN,β2-MG,NAG and WHOQOL-BRFE scores between the two groups before treatment (P ＞ 0.05).After treatment,ET-1,MDA,BUN and WHOQOLBRFE scores were significantly higher,and Kim-1,β2-MG and NAG were significantly lower than those before treatment,and the changes in the study group were more obvious than those in the control group (P ＜ 0.05).After treatment,the total effective rate of the study group was [90.00％ (54/60)] was higher than that of the control group [75.00％ (45/60)] (P ＜ 0.05).Conclusions Breviscapine adjuvant therapy is significantly effective in the treatment of patients with renal injury caused by extracorporeal shock wave therapy for renal calculi.It can improve the clinical curative effect,the prognosis and quality of life through effective regulation of related factors in serum biochemical indexes of renal injury.