摘要目的:探讨颗粒溶素在精索静脉曲张(VC)患者精液的表达水平及临床意义。方法:选择2016年9月至2017年7月在本院就诊的80例男性不育患者作为观察组，其中45例为原发性VC(VC不育组)，35例患者不合并VC(非VC不育组)。同时，本研究选取30例健康男性为可育对照组。检测所有入组精液精子密度、精子活动率、精子正常形态比例以及颗粒溶素的表达水平。结果:VC不育患者精浆颗粒溶素的表达水平均显著高于可育对照组；此外，与非VC不育患者相比较，VC不育患者精浆颗粒溶素水平更高；精浆颗粒溶素的表达与精子浓度(r＝－0.364， P<0.001)、精子活力(r＝－0.397， P<0.001)和精子正常形态(r＝－0.441， P<0.001)均呈负相关。 结论:不育合并VC患者精浆颗粒溶素表达水平显著高于正常健康人群，且其表达水平与VC等级密切相关。

abstractsObjective:To investigate clinic effect of seminal granulysin levels in infertile men with varicocoele.Methods:From September 2016 to July 2017, a total of 80 infertile patients as observed group, including infertile with varicocoele(n=45) and infertile without varicocoele (n=35), and 30 healthy men as control group were studied in this research. All participants had semen analysis and estimation of seminal granulysin expression.Results:Seminal granulysin expression was significantly higher in infertile men than control group. Among infertile men, seminal granulysin expression was significantly lower in those with VC than in those without. Besides, seminal granulysin expression was negatively correlated with sperm concentration(r=-0.364, P<0.001), sperm motility (r=-0.397, P<0.001), and sperm normal forms (r=-0.441, P<0.001). Conclusions:Seminal granulysin expression is significantly lower in infertile men than in fertile men being lowest in infertile men associated with VC. Granulysin levels are significantly correlated with VC grade.