摘要CIM+辅助性T细胞(Th)通常可分为Th0、Th1、Th2和Th3等细胞亚群.Th1细胞过去一直被认为是介导迟发型超敏反应、引起组织损伤的主要细胞.近年来发现一群主要分泌白细胞介素-17(IL-17)、不同于Th1/Th2的新型CD4+T细胞亚群-11117细胞.Th17细胞与自身免疫性疾病、肿瘤、炎性反应和移植排斥等的发生发展关系密切.

abstractsCD4+helperT(Th)cells were usually divided into Th0,Th1,Th2,and Th3 subsets over past sevend decades.Th1 cells were long thought to mediate delayed type hypersensitivity and cause tissue damage.Recent studies have defined a previously unknown subset of the CD4+T cells-the IL-17-producing T cells (Th17 lineage)that premises to change our understanding of immune resulation and immune pathogenesis.The mles of Th17 are being rapidly discovered and are providing insights into mechanisms of autoimmune diseases,tumor,inflammatory,graft rejection,etc.Th17 lineage development and its important implications for autoim mune diseases were reviewed in this paper.