摘要CD25+CD4+调节性T细胞(Treg)是显性耐受的重要调节细胞,在免疫病理、自身免疫耐受的维持、针对病原体和肿瘤的免疫反应调节过程中发挥着关键的作用.Foxp3作为X染色体编码的叉头蛋白转录因子家族的一员,是Treg发育、分化和功能发挥所必不可少的.研究Foxp3调控机制及其在Treg生物功能中的作用对于Treg和显性耐受的研究具有极其重要的意义.

abstractsCD25 + CD4 + regulatory T cells (Treg) , as important mediators of dominant tolerance, play a critical role in the immunopathogenesis, the maintenance of immunological tolerance to "self", and the regulation of immune responses to pathogens and tumors. Foxp3, an X chromosome-encoded forkhead transcription factor family member, is indispensable for the development, differentiation, and function of Treg. The investigation, including regulation mechanism of Foxp3 and its role in the biological function of Treg, is of great importance to the research of biological function of Treg and dominant tolerance.