换一批摘要免疫球蛋白样转录子(ILT)家族表达于髓系和淋巴系细胞表面,包括抑制性受体和激活性受体,通过与相应的配体结合发挥抑制或激活作用.配体包括MHC-Ⅰ类分子及其相关分子.由于抑制性受体与激活性受体特征相似,但在细胞内的功能却截然相反,因而研究ILT的结构、功能及其在临床相关疾病中的作用十分重要.
更多相关知识
abstractsImmunoglobulin-like transcript (ILT) family include inhibitory and stimulatory receptors which can be expressed on the surface of myeloid and lymphoid cells. They play the inhibitory or stimulatory role by combining their corresponding ligands that contain major histocompatibility complex Ⅰ ( MHC- Ⅰ ) and their relevant molecules. The receptor isoforms share similar specificties but have opposite functions on the same cell. Here we emphasize the structure and function of ILT family as well as their application in related clinical diseases.
More相关知识
关键词
免疫球蛋白样转录子MHC-Ⅰ类分子树突状细胞免疫调节Immunoglobulin-like transcriptMHC- ⅠDendritic cellImmunological regulation
分类号
R3（基础医学）
DOI
10.3760/cma.j.issn.1673-4394.2010.05.010
发布时间
2010-10-25（万方平台首次上网日期，不代表论文的发表时间）
- 浏览150
- 被引0
- 下载24
相似文献
- 中文期刊
- 外文期刊
- 学位论文
- 会议论文
