换一批
换一批摘要IL-21是最近发现的一种I型细胞因子,由活化的CD4+T细胞产生,特别是Th2细胞.IL-21R在正常的淋巴组织包括脾、胸腺、淋巴结、外周血淋巴细胞、纤维化肺组织中都有表达.IL-21特异性结合IL-21 R介导多种生物学效应,对不同阶段B、T淋巴细胞的分化和自然杀伤(NK)细胞的增殖均起重要作用.因此IL-21有着广泛的生物学功能,在各种疾病包括病毒感染中扮演着重要的角色.
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abstractsInterleukin 21 is a newlyfound type Ⅰ cytokine which is produced by activated CD4 + T cells especially the Th2 cells. The receptor for IL-21 is expressed on normal lymphatic tissues such as spleen, thymus, lymth nodes, peripheral blood lymphocytes, fibrosis lung. As its receptor is expressed widely, IL-21 is thought to involve in B and T cell differentiation, as well as NK cell proliferation. IL-21 has varieties of biological functions and play a significant role in many diseases including viral infections.
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分类号
R3
DOI
10.3760/cma.j.issn.1673-4394.2011.02.003
发布时间
2011-06-08
基金项目
国家自然科学基金资助项目
辽宁省自然科学基金
辽宁省科技攻关计划
沈阳市科学技术计划项目
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