摘要B淋巴细胞是体内唯一能够产生抗体的细胞,介导体液免疫.B淋巴细胞发育分化是一个十分有序的过程,大体分为五个阶段,祖B细胞、前B细胞、未成熟B细胞、过渡B细胞和成熟B细胞.每个阶段均有特征性的表面标志,其表面分子的表达呈规律性改变.各发育分化阶段特征性表面分子表达异常可引起某些疾病,虽然目前国外对B淋巴细胞发育分化情况有较多研究,但对于B淋巴细胞发育分化过程中的一些问题及对某些疾病的影响与相关机制仍不明确,需进一步研究.

abstractsB lymphocytes is the only one can produce antibody in body.It can mediate humoral immunity.B-cell development and differentiation are an orderly process.B-cell development and differentiation are divided into five stages,pro-B cells,pre-B cells,immature B cells,transitional B cells and mature B cells.There are characteristic surface markers in each stage of B-cell development and differentiation.Expression of surface molecules shows regular changes.In each development and differentiation stage abnormal expression of characteristic surface molecules could cause diseases.Although there are a lot of researches on the development and differentiation of B cells,the development and differentiation of B cells is still unclear.