摘要NK细胞是固有免疫系统的重要组成部分,可特异直接杀伤靶细胞,也可分泌细胞因子或趋化因子调节其他免疫细胞的活性,进而激活机体的适应性免疫.生理情况下,NK细胞对自身正常组织细胞耐受,这种平衡依赖于特定环境下NK细胞表面多样性受体与MHC-Ⅰ类分子的相互作用,然而并非所有的NK细胞都表达识别MHC-Ⅰ类分子的抑制性受体.NK细胞发育在NK细胞诱导耐受的过程中发挥着重要作用,相关研究对临床应用具有重要意义.

abstractsNatural killer (NK)cells are the key component of the innate immunity system,which kill target cells non-specifically and directly or activate the specific immunity by regulating the activation of other immune cells through secretion of cytokines or chemotactic factors.Under physiological condition,NK cells are tolerant to normal tissues and cells.This balance depends on the interaction of NK cells' diverse surface receptors with major histocompatibility complex(MHC) class Ⅰ molecules in the specific settings.However,not all NK cells express inhibitory receptors that recognize MHC class Ⅰ proteins on the cell surface of self-tissues.NK cell development is important in the induction of immune tolerance.The related studies are of great significance to clinical applications.