摘要目的 研究海南汉族人群MICA基因的多态性与肺癌的相关性.方法 采用PCR-SSP和PCR-SBT方法对样本MICA基因的多态性进行检测分析.结果 肺癌患者中有1 1种MICA等位基因被检测出来,MICA* A5/010基因频率在肺癌组中明显增高(MICA* A5:OR=1.62,95％ CI:1.18～2.23,Pc ＜0.05;MICA *010:OR=6.13,95％ CI:3.5～10.75,Pc＜0.000).结论 MICA* A5/010基因可能与肺癌的易感性相关.

abstractsObjective To study the correlation between polymorphism of MICA gene and lung cancer in Han nationality of Hainan.Methods PCR-SSP and PCR-SBT were used to analyze the gene polymorphism of MICA.Results 11 allelic genes were found in lung cancer patients.The frequency of MICA * A5/ 010 was significantly higher in lung cancer group than that of control group (MICA * A5:OR =1.62,95％ CI:1.18-2.23,Pc＜0.05;MICA *010:OR=6.13,95％CI:3.5～10.75,Pc＜0.000).Conclusions MICA * A5/010 allelic gene may be associated with the susceptibility to lung cancer.