摘要白细胞介素(interleukin,IL)36是一种新型促炎因子,可由皮肤、滑膜、结肠黏膜等多种类型的细胞产生,IL-36可诱导炎症介质的产生并促进树突状细胞的成熟.IL-36可被中性粒细胞来源的酶强有力激活,通过与一种异质二聚体受体结合组成IL-36R亚基和IL-1RAcP激活MAPK和NF-KB/AP-1等重要信号通路,在人类先固有免疫和适应性性免疫中发挥着重要作用,研究发现,IL-36对慢性炎症的发生发展及诊断和预后具有重要的参考价值,有望成为慢性炎性疾病基因诊疗的新靶点.

abstractsInterleukin (IL)-36 is a new type of pro-inflammatory factor,and various types of cells in skin,synovial membrane and colonic mucosa can induce them.IL-36 can promoted the produced inflammatory medium the maturation of dendritic cells,and can be activated by the enzyme of neutrophil.IL-36 can activated important signaling pathways such as MAPK and NF-κB/AP-1 by binding to a heterodimeric recptor consisting of the IL-36 receptor(IL-36R) subunit and the IL-1R accessory protein(IL-1RAcP),and plays an important role in the human inherent immunity and adaptive immunity.The research found IL-36 has important reference value for the occurrence,development,diagnosis and prognosis of chronic inflammation,and is epected to be a new target for gene diagnosis and treatment of chronic inflammatory diseases.