摘要目的 探讨血液参数平均血小板体积(mean platelet volume,MPV),中性粒细胞与淋巴细胞比(neutrophil to lymphocyte ratio,NLR),血小板与淋巴细胞比(platelet to lymphocyte ratio,PLR)在布鲁氏杆菌病(简称布病)中的诊断价值.方法 回顾性分析2016年6月至2017年6月在黑龙江省农垦总局总医院确诊的200例布病患者,200名年龄和性别匹配的健康体检患者作为对照组.比较白细胞计数(white blood cell,WBC),中性粒细胞计数,淋巴细胞计数,血小板计数(platelet,PLT),血红蛋白(hemo-globin,Hb)及平均血小板体积(mean platelet volume,MPV),中性粒细胞与淋巴细胞比(neutrophil to lym-phocyte ratio,NLR),血小板与淋巴细胞比(platelet to lymphocyte ratio,PLR).同时对部分常见的炎症标记物如红细胞沉降率(erytrocyte sedimentation rate,ESR)、超敏C反应蛋白(hypersensitive C-reactive pro-tein,hs-CRP),也进行了比较.结果 分析结果显示WBC计数、中性粒细胞计数、Hb和NLR值在患者组与对照组之间存在统计学差异(P<0.05).淋巴细胞计数、血小板计数、MPV、PLR在患者组与对照组之间差异没有统计学意义(P>0.05).当患者被分为关节炎阳性组和关节炎阴性组时,与对照组比较,NLR在关节炎阳性组更有意义(P=0.009).Hb在关节炎阳性组和对照组之间也差异有统计学意义(P<0.05).此外,我们还发现患者组与对照组ESR、hs-CRP结果差异有统计学意义(P<0.05).结论 NLR值可以作为布鲁氏菌病的炎症标志物.NLR在患有布鲁氏病关节炎的患者中更具有价值.

abstractsObjective To investigate diagnostic value of mean platelet volume(MPV),neutrophil to lymphocyte ratio(NLR)and platelet to lymphocyte ratio(PLR)in brucellosis disease. Methods In this retro-spective study,we reviewed 200 cases of patientswith confirmed brucellosis in the General Hospital of Hei-longjiang Province Land Reclamation Bureau during June 2016 to June 2017,200 healthy people with matched-age and sex were recruited as control group. White blood cell (WBC)count,neutrophil count,lymphocyte count,platelet count,hemoglobin (Hb),MPV,NLR and PLR were determined. In addition,inflammatory mark-ers such as erytrocyte sedimentation rate(ESR)and hypersensitive C-reactive protein (hs-CRP)were also ana-lyzed. Results WBC count,neutrophil count,Hb and NLR were significantly different between the patient group and the control group(P < 0. 05). There was no significant difference in lymphocyte count,platelet count, MPV and PLR between the patient and control group(P > 0. 05). NLR was more significantly different between patients with arthritis and that without arthritis(P = 0. 009). The difference of Hb was also significant between patients with arthritis and without arthritis(P < 0. 05). ESR and (hs-CRP)were also different between patients and controls (P < 0. 05). Conclusion NLR can be used as an inflammatory marker for Brucellosis. In addi-tion,NLR is more valuable for the diagnosis of patients with brucella arthritis.