摘要目的 探讨新疆哈萨克族食管病变中人类乳突状瘤病毒(human papilloma viruses,HPV)-L1蛋白表达的差异性.方法 选取2015年5月至2017年12月在新疆维吾尔自治区人民医院经胃镜检查确诊为食管病变的300例哈萨克族患者,记录患者的临床病理结果 ,采用免疫组化方法检测HPV-L1蛋白的表达阳性情况,并进行临床病理结果与HPV-L1蛋白表达的相关性分析.结果 在300例患者中,食管癌50例,检出率是16.67％;HPV-L1蛋白表达阳性34例,阳性率为11.33％,在食管癌患者中HPV-L1蛋白的阳性率为64.00％.HPV-L1蛋白表达阳性率与食管癌的Dukes分期、淋巴结转移、浸润深度呈正相关(P<0.05),与组织学分化程度呈显著负相关(P<0.05).Cox回归模型分析显示淋巴结转移、Dukes分期、组织学分化程度、浸润深度为影响患者HPV-L1蛋白表达阳性率的危险因素(P<0.05).结论 新疆哈萨克族食管病变中食管癌的发生率比较高,多表现为HPV-L1蛋白表达阳性,且HPV-L1蛋白与患者的临床特征有相关性.

abstractsObjective To investigate the differential expression of human papilloma viruses(HPV)-L1 protein in Xinjiang Kazakh's esophageal lesions. Methods From May 2015 to December 2017,300 esophageal lesions with endoscopy in the Xinjiang Uiger Municipal People's Hospital patients were selected,and the clinical pathological data were recorded. The HPV-L1 protein expression was detected by immunohistochemical method, as the same time,the correlation of clinical pathological and expression of HPV-L1 protein was analyzed. Re-sults There were 50 patients of esophageal tumors in the 300 patients,the detection rate of esophageal cancer was 16. 67 ％,the expression of HPV-L1 shell protein was 34 cases,the positive rate was 11. 33 ％,while the positive rate in esophageal cancer was 64. 00％ . The positive rate of HPV-L1 shell protein expression were posi-tively correlated with Dukes stage,lymph node metastasis and depth of invasion(P < 0. 05),and were negatively correlated with histological differentiation(P < 0. 05). Cox regression analysis showed that lymph node metasta-sis,Dukes stage,histological differentiation and depth of invasion were the risk factors those influenced the posi-tive rate of HPV-L1 protein expression(P < 0. 05). Conclusions The incidence of esophageal cancer in Xin-jiang Kazakh esophagus lesions is relatively high. Immunohistochemistry result | shows that the expression of HPV-L1 protein has significant correlation with the pathological characteristics of the patients.