摘要随着中国人群肿瘤发病率和死亡率不断攀升，癌症已成为我国城乡居民的主要死因，其中结直肠癌(colorectal cancer，CRC)是肿瘤相关致死的第二高发疾病。探究CRC发生发展机制、寻找新的肿瘤治疗方式对CRC治疗及预后具有重要意义。CRC发生发展与多种因素密切相关，其中可选择性多聚腺苷酸化(alternative polyadenylation，APA)参与的应激调控在肿瘤发生发展中具有重要作用。文章就APA、应激与CRC的网络关系，RNA结合蛋白参与的APA过程在应激及肿瘤发生发展中的作用进行综述。

abstractsWith the increasing incidence rate and mortality of cancer in Chinese population, cancer has become the main cause of death for urban and rural residents in China. Among which colorectal cancer (CRC) is the second highest incidence of cancer related deaths. Exploring the pathogenesis and development of CRC, as well as finding new tumor treatment methods is of great significance to the treatment and prognosis of CRC. The occurrence and development of CRC are closely related to many factors. The stress regulation involving alternative polyadenylation (APA) plays an important role in the occurrence and development of tumors. This review summarizes the network relationship between APA, stress and CRC, as well as the role of RNA binding proteins in the APA process in stress and tumor development.