摘要促红细胞生成素肝细胞激酶(erythropoietin-producing hepatocellular receptor，Eph)受体是酪氨酸激酶受体中最大的一个家族，Eph受体及其膜锚定配体Ephrin介导的信号传导依赖于细胞与细胞间的直接接触，同时由于其具有受体-配体复合物的结构特点及其独特的相互作用模式，因而可与多种微生物细胞表面的病原相关分子模式相结合，通过不同的信号转导途径，进而在多种感染性疾病的发生、发展中发挥重要作用，具有广泛的临床研究价值。文章就Eph家族受体信号转导途径在细菌、真菌、病毒、寄生虫等多种感染性疾病中的调控机制展开了综述，为其在感染性疾病相关的基础研究、临床应用等方面提供理论依据。

abstractsErythropoietin-producing hepatocellular receptor(Eph) receptors are the most prominent family of receptor tyrosine kinases, and the signaling mediated by Eph receptors and their membrane-anchored ligand, Ephrin, depends on direct cell-to-cell contact. Meanwhile, due to their structural features of receptor-ligand complexes and unique interaction patterns, they can bind to pathogen-associated molecular patterns on the surface of various microbial cells and play an important role in developing various infectious diseases through different signaling. The Eph family of receptors has a wide range of clinical research value because of its structural characteristics and unique interaction patterns. This review focuses on the regulation mechanism of the Eph/ephrin signaling transduction pathway in bacteria, fungi, viruses, parasites, and other infectious diseases and provides a theoretical basis for their basic research and clinical application in infectious diseases.