摘要背景 炎症消退一直被认为是被动的过程,现已证实其是一个由内源性抗炎、促炎症消退介质控制的主动的程序化过程.目的 目前人们对炎症消退机制的研究正逐步深入,因此,了解炎症消退的研究现状以及未来发展趋势是十分必要的.内窖炎症消退是一个由多种细胞参与,抗炎、促炎症消退介质控制的复杂过程.这些介质通过下调促炎介质基因的表达、抑制炎症细胞的浸润、诱导炎症细胞凋亡以及促进凋亡细胞吞噬等环节精密地调节炎症的发展与消退.现就具有抗炎、促炎症消退双重作用的内源性脂质介质以及炎症消退的新的细胞分子机制进行简要综述.趋向 炎症消退已成为炎症研究的新方向,促进炎症消退也成为炎症治疗的一种新策略.在研究炎症消退机制的基础上研发促炎症消退的药物为炎症性疾病治疗提供了新的途径.

abstractsBackground Once thought to be a passive process, the resolution of inflammation is now shown to involve active biochemical programmes controlled by endogenous anti-inflammatory and pro-resolution mediators, such as lipoxins and resolvias.Purpose The anti-inflammatory and pro-resolution mediators and cellular mechanisms of inflammation resolution have become increasingly well characterized. So, it is important to know about the present status and probable future trends of inflammation resolution. Content This review presents an update and overview of new cellular and molecular mechanisms for the resolution of inflammation, revealing key roles for lipoxins, cyclopentenone prostaglandins and recently discovered families of endogenous mediators, termed resolvins and protectins. These mediators have anti-inflammatory and pro-resolution properties, thereby suppressing pro-inflammatory gene expression and cell trafficking, inducing inflammatory-cell apoptosis and phagocytosis. Trend Developing drugs based on endogenous mediators and mechanisms that are inherent to resolution might represent a new strategy in antiinflammatory therapy. It is thought that this strategy will open up new avenues for the future management of inflammation-based diseases.